科研项目： 1.国家自然科学基金青年科学基金项目，基于“全景-靶向-精准”多维整合分析策略研究刺五加叶治疗缺血性脑卒中的药效物质基础及作用机制，2025.01-2027.12，主持。 2.吉林省科技厅人才专项-青年成长科技项目，基于多组学结合质谱成像技术研究生脉散治疗缺血性脑卒中的药效物质基础及作用机制，2024.01-2025.12，主持。 3.吉林省教育厅优秀青年项目，生脉散调控微生物-肠-脑轴治疗缺血性脑卒中的作用机制研究，2024.01-2025.12，主持。 4.入选吉林大学励新优秀青年教师培养计划（重点培养阶段），2024-2026。 5.吉林大学白求恩计划项目，2024.01-2025.12，主持。 6.吉林大学博士研究生交叉学科科研资助计划，2019-2020，主持。 7.吉林省科技厅科技发展计划项目，五味子等中药饮片炮制规范及质量标准研究，2019.01-2021.12，参与。 8.国家自然科学基金面上项目，基于药物代谢组学及系统药理学技术研究刺五加叶治疗缺血性脑中风的药效物质基础及作用机制，2016.01-2019.12，参与。 代表性学术论文： [1]Wang R, Liu S, Liu Z*,et al. Mass spectrometry-based serum lipidomics strategy to explore the mechanism of Eleutherococcus senticosus (Rupr. & Maxim.) Maxim. leaves in the treatment of ischemic stroke.Food & Funct. 2021, 12(10):4519-4534. [2]Wang R, Sun Y, Liu Z*,et al. Therapeutic effect of Eleutherococcus senticosus (Rupr. & Maxim.) Maxim. leaves on ischemic stroke via the microbiota-gut-brain axis.Phytother Res. 2023, 37(10):4801-4818. [3]Wang R, Shi L, Liu Z*,et al. Mass spectrometry-based urinary metabolomics for the investigation on the mechanism of action of Eleutherococcus senticosus (Rupr. & Maxim.) Maxim. leaves against ischemic stroke in rats.J Ethnopharmacol. 2019, 241,111969. [4]Wang R, Tang S, Liu Z*,et al. Integrated ultra-high-performance liquid chromatography coupled with quadrupole-orbitrap mass spectrometry-based components analysis and network pharmacology strategy of Gancao Xiexin Decoction in treating gastric ulcer.J Sep Sci. 2024, 47(1):e2300751. [5] Chen Z, Liu S,Wang R*, Liu Z*,et al. Integrated metabolome and microbiome strategy reveals the therapeutic effect of nervonic acid on Alzheimer's disease rats.J Nutr Biochem. 2024. [6] Song T,Wang R(Co-first author), Liu Z*,et al. Metabolomics and molecular dynamics unveil the therapeutic potential of epalrestat in diabetic nephropathy.Int Immunopharmacol. 2024. [7] Chen Z, Liu S,Wang R*, Liu Z*,et al. UPLC-Q-TOF/MS based serum and urine metabolomics strategy to analyze the mechanism of nervonic acid in treating Alzheimer's disease.J Pharm Biomed Anal. 2024, 240:115930. [8] Shi L,Wang R, Liu Z*,et al. A rapid protocol to distinguish between Citri Exocarpium Rubrum and Citri Reticulatae Pericarpium based on characteristic fingerprint and UHPLC-Q-TOF MS methods.Food & Funct. 2020, 11(4):3719-3729. [9] Wang Y,Wang R, Liu Z*,et al. Systematic studies on the in vivo substance basis and the pharmacological mechanism of Acanthopanax Senticosus Harms leaves by UPLC-Q-TOF-MS coupled with a target-network method.Food & Funct. 2018, 9(12):6555-6565. [10] Wang Y,Wang R, Liu Z*,et al. Study on the therapeutic material basis and effect of Acanthopanax senticosus (Rupr. et Maxim.) Harms leaves in the treatment of ischemic stroke by PK-PD analysis based on online microdialysis-LC-MS/MS method.Food & Funct. 2020, 11(3):2005-2016. [11] Zhou H, Chen Z, Li J,Wang R,et al. Dietary Supplementation with Nervonic Acid Ameliorates Cerebral Ischemia-Reperfusion Injury by Modulating of Gut Microbiota Composition-Fecal Metabolites Interaction.Mol Nutr Food Res. 2024. [12] Liu Y, Wei M, Yue K,Wang R, Liu Z*,et al. Non-target metabonomic method provided new insights on the therapeutical mechanism of Gancao Fuzi decoction on rheumatoid arthritis rats.Journal of chromatography B, Analytical technologies in the biomedical and life sciences. 2019,1105:93-103. 获奖情况： 2022年吉林省优秀博士学位论文 |
