Associate Professor Sun Weilun’s Team Uncovers a Novel Mechanism by Which Ginsenoside Rg2 Alleviates Secondary Brain Injury after Intracerebral Hemorrhage

Recently, a research article led by the team of Associate Professor Sun Weilun from the School of Pharmaceutical Sciences, Jilin University, was published online in Journal of Neuroinflammation. The paper is titled “Ginsenoside Rg2 attenuates secondary brain injury following intracerebral hemorrhage by inhibiting NLRP3-mediated pyroptosis”.

The research first systematically characterized the neuroprotective efficacy of ginsenoside Rg2 using an intracerebral hemorrhage animal model. Subsequent mechanistic investigations verified that the neuroprotective benefits of Rg2 are tightly linked to microglia-mediated pathways. Beyond its protective effects in the acute phase of brain hemorrhage, the team also evaluated the long-term therapeutic impacts of Rg2.

Collectively, this work systematically dissects the pathological mechanisms underlying secondary brain injury post intracerebral hemorrhage from the perspective of neuroinflammation and NLRP3 inflammasome-driven pyroptosis. It delivers solid experimental evidence for developing interventional therapeutics targeting hemorrhagic brain damage, and opens up a new research frontier for translating natural bioactive compounds into treatments for central nervous system disorders.

Sun Han, a postgraduate student at the School of Pharmaceutical Sciences, and Senior Engineer Fu Wenwen serve as co-first authors of this paper. Corresponding author is Associate Professor Sun Weilun. The School of Pharmaceutical Sciences, Jilin University is designated as the primary affiliation of this study. This research was jointly supported by the National Natural Science Foundation of China, the Science and Technology Development Program of Jilin Province, and the China Postdoctoral Science Foundation.