办公地点

药学院204

办公电话

0431-85619716

邮箱

zxm@jlu.edu.cn

教育背景

2003-2007 PhD, School of Pharmacy, Jilin University 2003-2007 吉林大学药学院 博士研究生 2000-2003 MS ,School of Pharmacy, Jilin University 2000-2003 吉林大学药学院 硕士研究生

工作经历

2003.07—2006.01 Lecture, Department of Biochemisty and molecular biology, Institute of Frontier Medical Science, Jilin University 吉林大学再生医学科学研究所生物化学研究室讲师

2006.01—2009.03 Associate professor& Master Supervisor,, Department of Biochemisty and molecular biology, Institute of Frontier Medical Science, Jilin University 吉林大学再生医学科学研究所生物化学研究室 副教授

2009.03— Associate Professor & Master Supervisor, School of Pharmaceutical Sciences, Jilin University 吉林大学药学院生物药学系

主讲课程

生物制品鉴定学 生物医学工程研究进展

研究领域

My Career goals is to explore the fundamental mechanism of Neurodegeneration and Parkinson's disease and potential targets for therapeutic intervention and to look for new agents in parkinson’s disease treatment. 主要从事神经退行性疾病帕金森病等疾病的发病机制和治疗新药的筛选和研究工作。

科研成果

1. Bharati Sinha,Qiaofeng Wu,WeiLi, Xinmu Zhang, Protection of melatonin in experimental models of newborn hypoxic-ischemic brain injury through MT1 receptor. Journal of Pineal Research. J Pineal Res. 2018 Jan;64(1).

2. Mingchang Li, Wei Wang, Haojian Mai, Xinmu Zhang, Jian Wang, Yufeng Gao, Yuefei Wang, Gang Deng, Ling Gao, Shuanhu Zhou, Qianxue Chen,Xin Wang. Methazolamide improves neurological behavior by inhibition of neuron apoptosis in subarachnoid hemorrhage mice. Sci Rep. 2016; Oct 12;(6):35055-35068.

3. Xinmu Zhang, Yingzi Wang, Cheng Ma, Yan Yan, Yang Yang, Xin Wang, Wolf-Dieter Rausch.Ginsenoside Rd and ginsenoside Re offer neuroprotectionin a novel model of Parkinson’s disease. Am J Neurodegener Dis 2016;5(1):52-61.

4. Rose Du, Jing Zhou, Svetlana Lorenzano, Wenming Liu, NareeratCharoenvimolphan, Baogang Qian,Jun Xu, JianWang, Xinmu Zhang, XinWang, Friedlander RM, Paigen B, Weiss ST. Integrative Mouse and Human Studies Implicate ANGPT1 and ZBTB7C as Susceptibility Genes to Ischemic Injury. Stroke 15;46(12) :3514-3522.

5. Ana C. Sirianni, Jiying Jiang, Jiang Zeng, Lilly L. Mao, Shuanhu Zhou, Peter Sugarbaker, Xinmu Zhang, Wei Li, Robert M. Friedlander and Xin Wang. N-acetyl-L-tryptophan, but not N-acetyl-Dtryptophan, rescues neuronal cell death in models of amyotrophic lateral sclerosis. Journal of Neurochemistry. 2015 Sep;134(5):956-68.

6. Yingyu Zhang, Meng C, Xinmu Zhang, Yuan CH, Wen MD, Chen Z, Dong DC, Gao YH, Liu C, Zhang Z. Ophiopogonin D attenuates doxorubicin-induced autophagic cell death by relieving mitochondrial damage in vitro and in vivo. The Journal Pharmacology of Experimental Therapeutics.2015 Jan;352(1):166-174.

7. Hua Zhou,Jian Wang, Jiying Jiang, Irina G. Stavrovskaya, Mingchang Li, Wei Li, Qiaofeng Wu, Xinmu Zhang,Chengliang Luo, Shuanhu Zhou, Ana C. Sirianni, Sovan Sarkar, Bruce S. Kristal, Robert M. Friedlander, and Xin Wang. N-Acetyl-Serotonin Offers Neuroprotection through Inhibiting Mitochondrial Death Pathways and Autophagic Activation in Experimental Models of Ischemic Injury. The Journal of Neuroscience, 2014 ;34(8):2967–2978.

8. ChengLiang Luo, QianqianLi, XipingChen, XinmuZhang, LiliangLi. Lipoxin A4 attenuates brain damage and downregulates the production of pro-inflammatory cytokines and phosphorylated mitogen-activated protein kinases in a mouse model of traumatic brain injury. Brain Research,2013; 1502,1-10.

9. Haiying Wang, Meishan Jin, Xinmu Zhang. Expressions of surviving galectin-3 and TPO papillary thyoid microcarcinoma tissue and their clinical signifcances. Journal of Jilin University( MedicineEdition) 2014;40(1) :150 -154.

10. Xinmu Zhang, Yingyu Zhang, LvYudan, LinWeihong, Baoshuang, WangZang. Effect of TAT fusion protein on apoptosis in ischemic stroke. Chinese Journal of Gerontology 2013;33(11) :5494-5495.