Xu Hui

author: Time:2023-04-04 Number of hits:

Name

Hui Xu

Title

Professor, Doctoral supervisor

Address

Room 409, Department of Regenerative Medical

Tel.

0431-85619135

Email

xu_hui@jlu.edu.cn


Education Background

1993-1998 Bachlor, Clinical Medicine, Inner Mongolia Medical University. 1998-2001 Master, Pathology, School of Pharmacitical Science, Jilin University

2001-2004 Medical Doctor, Pathology, School of Pharmacitical Science, Jilin University

Work Experience

2011- Professor & doctoral supervisor, School of Pharmacitical Science, Jilin University. 2006-2011 Vice Professor & master supervisor, School of Pharmacitical Science, Jilin University. 2004-2006,Lecturer, School of Pharmacitical Science, Jilin University.2001-2004 assistant, School of Pharmacitical Science, Jilin University

Courses

Proteomics, Guide to Academic Writing,Pharmacognosy

Research Field

Metabotic bone disease, Osteoporosis, Skeletal Fluorosis

Scientific Research Achievements

Publications:

Representative Articles

1. Effect of flavonoids from Rhizoma Drynariae on osteoporosis rats and osteocytes. Biomed Pharmacother. 2022, 153: 113379.

2. Role of TGF-beta1 in fluoride-treated osteoblasts at different stages. Biol Trace Elem Res. 2022 Feb;200(2):740-748

3. Effect of fluoride on osteocyte-driven osteoclastic differentiation. Toxicology. 2020 APR 30;436:152429.

4. The antiresoptive effects of recombinant Lingzhi-8 protein against retinoic acid-induced osteopenia. Euro J Pharmacol 2019 Sept; 863; 172699

5. Different effects of fluoride exposure on the three major bone cell types. Biol Trace Elem Res. 2020 Jan, 193(1): 226-233.

6. Requirement of TGFβ signaling for effect of fluoride on osteoblastic differentiation. Biol Trace Elem Res. 2019 Feb;187(2):492-498.

7. Role of PTH on fluoride-affected osteoclastic differentiation induced by co-culture with osteocytes. Report on the xxxivth conference of the International Society of Fluoride Research. 2018.

8. PTH (1-34) affects bone turnover governed by osteocytes exposed to fluoride. Toxicol Lett. 2018 May; 288:25-34

9. The role of TGFβ receptor 1-smad3 signaling in regulating the osteoclastic mode affected by fluoride. Toxicology. 2018 Jan; 393:73-82.

10. Preliminary Analysis of MicroRNAs expression profiling in MC3T3-E1 cells exposed to fluoride. Biol Trace Elem Res. 2017 Apr; 176(2):367-373.

11. Treatment and Prevention of Skeletal Fluorosis. Biomed Environ Sci. 2017; 30(2): 147-149.

12. Oxidative stress in mechanism underlying Streptozotocin aggravated dental fluorosis. Fluoride. 2016 (Jul-Sep), 49(3): 327-335

13. Analysis of the role of insulin signaling in bone turnover induced by fluoride. Biol Trace Elem Res. 2016 Jun; 171(2):380-390.

14. Streptozotocin aggravated osteopathology and insulin induced osteogenesis through co-treatment with fluoride. Biol Trace Elem Res. 2015 Dec; 168(2):453-461.

15. A role for PERK in the mechanism underlying fluoride-induced bone turnover. Toxicology. 2014 Nov; 325:52-66.

16. Effect of siRNA PERK on fluoride-induced osteoblastic differentiation in OS732 cells. Biol Trace Elem Res. 2014 Jun; 159(1-3):434-439.

17. Role of unfolded protein response in affecting osteoblast differentiation induced by fluoride. Biol Trace Elem Res. 2014 Apr; 158(1):113-121.

18. Role of endoplasmic reticulum stress in aberrant activation of fluoride-treated osteoblasts. Biol Trace Elem Res. 2013, Sep; 154(3):448-456.

19. Effect of fluoride on insulin level of rats and insulin receptor expression in the MC3T3-E1 cells. Biol Trace Elem Res. 2012 Dec; 150(1-3):297-305.

20. Fluoride-induced oxidative stress in three-dimensional culture of OS732 cells and rats. Biol Trace Elem Res. 2011 Oct; 143(1):446-456.

21. Activation of PERK signaling through fluoride-mediated endoplasmic reticulum stress in OS732 cells. Toxicology. 2010 Nov; 277(1-3): 1-5.

22. Elevation of PTH and PTHrp induced by excessive fluoride in rats on a calcium-deficient diet. Biol Trace Elem Res. 2010 Oct; 137(1):79-87.

23. Proteomic analysis of osteoblasts exposed to fluoride in vitro. Biol Trace Elem Res. 2008 June; 123(1-3):91-97.

24. Role of oxidative stress in osteoblasts exposed to sodium fluoride. Biol Trace Elem Res. 2008 June, 123(1-3):109-115.

25. Effects of fluoride on the intracellular free Ca2+ and Ca2+-ATPase of kidney. Biol Trace Elem Res. 2007 June; 116(3):279-288.

26. Effect of sodium fluoride on the expression of bcl-2 family and osteopontin in rat renal tubular cells. Biol Trace Elem Res. 2006 Jan; 109(1):55-60.

27. Proteomic analysis of kidney in fluoride-treated rat. Toxicol Lett. 2005 Dec; 160(1):69-75.

28. Role of oxidative stress in fluoride-exposed osteoblasts. Report on XXVIth conference of the international society for fluoride research. 2007.

Books

1. Coal-burning Type of Endemic Fluorosis Pathophysiology and Clinical Treatments. 2021.10.27. Springer Singapore.

2. Experimental Diagnosis of Bone Metabolism. Chemical Industry Press Co., Ltd. Jan 2020

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